<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mathe, Janos</style></author><author><style face="normal" font="default" size="100%">Werner, Jan</style></author><author><style face="normal" font="default" size="100%">Lee, Yonghwan</style></author><author><style face="normal" font="default" size="100%">Bradley A. Malin</style></author><author><style face="normal" font="default" size="100%">Ledeczi, Akos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Model-Based Design of Clinical Information Systems</style></title><secondary-title><style face="normal" font="default" size="100%">Methods of Information in Medicine</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2008</style></date></pub-dates></dates><urls><related-urls><url><style face="normal" font="default" size="100%">http://www.isis.vanderbilt.edu/sites/default/files/Mathe.et_.al-MoIiM.2008.Paper-MBD_of_CIS.pdf</style></url></related-urls></urls><number><style face="normal" font="default" size="100%">5</style></number><volume><style face="normal" font="default" size="100%">47</style></volume><pages><style face="normal" font="default" size="100%">10</style></pages><abstract><style face="normal" font="default" size="100%">Objective: The goal of this research is to provide a framework to enable the model-based development, simulation, and deployment of clinical information system prototypes with mechanisms that enforce security and privacy policies.

Methods: We developed the Model-Integrated Clinical Information System (MICIS), a software toolkit that is based on model-based design techniques and high-level modeling abstractions to represent complex clinical workflows in a service-oriented architecture paradigm. MICIS translates models into executable constructs, such as web service descriptions, business process execution language procedures, and deployment instructions. MICIS models are enriched with formal security and privacy specifications, which are enforced within the execution environment.

Results: We successfully validated our design platform by modeling multiple clinical workflows and deploying them onto the execution platform.

Conclusions: The model-based approach shows great promise for developing, simulating, and evolving clinical information systems with formal properties and policy restrictions.</style></abstract><work-type><style face="normal" font="default" size="100%">Special Topic: Model-based Design of Trustwothy Health Information Systems</style></work-type><section><style face="normal" font="default" size="100%">399</style></section></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jason B. Martin</style></author><author><style face="normal" font="default" size="100%">Mathe, Janos</style></author><author><style face="normal" font="default" size="100%">Miller, Peter</style></author><author><style face="normal" font="default" size="100%">Ledeczi, Akos</style></author><author><style face="normal" font="default" size="100%">Weavind, Liza</style></author><author><style face="normal" font="default" size="100%">Miller, Anne</style></author><author><style face="normal" font="default" size="100%">David J. Maron</style></author><author><style face="normal" font="default" size="100%">Nadas, Andras</style></author><author><style face="normal" font="default" size="100%">Sztipanovits, Janos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Model-Integrated Approach to Implementing Individualized Patient Care Plans Based on Guideline-Driven Clinical Decision Support and Process Management - A Progress Report</style></title><secondary-title><style face="normal" font="default" size="100%">2nd International Workshop on Model-Based Design of Trustworthy Health Information Systems (MOTHIS 2008)</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">10/2008</style></date></pub-dates></dates><urls><related-urls><url><style face="normal" font="default" size="100%">http://www.isis.vanderbilt.edu/sites/default/files/Martin.et_.al_.MOTHIS.2008.Paper-CPM.pdf</style></url></related-urls></urls><abstract><style face="normal" font="default" size="100%">Standardizing the care of patients with complex problems in hospital settings is a challenge for physicians, nurses and other medical professionals. In acute care settings such as intensive care units, the inherent problems of stabilizing and improving vital patient parameters is complicated by the division of responsibilities among different individuals and teams. The use of evidence-based guidelines for managing complex clinical problems has become the standard of practice. Computerized support for implementing such guidelines has tremendous potential. The use of model-based techniques for specifying and implementing guidelines as coordinated asynchronous processes is a promising new methodology for providing advanced clinical decision support. Combined with visual dashboards, which show the status of the implemented guidelines, a new approach to computer-supported care is possible. These techniques are being applied to the management of sepsis in acute care settings at Vanderbilt Medical Center.</style></abstract></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Werner, Jan</style></author><author><style face="normal" font="default" size="100%">Mathe, Janos</style></author><author><style face="normal" font="default" size="100%">Duncavage, Sean</style></author><author><style face="normal" font="default" size="100%">Bradley A. Malin</style></author><author><style face="normal" font="default" size="100%">Ledeczi, Akos</style></author><author><style face="normal" font="default" size="100%">Jirjis, Jim</style></author><author><style face="normal" font="default" size="100%">Sztipanovits, Janos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Platform-Based Design for Clinical Information Systems</style></title><secondary-title><style face="normal" font="default" size="100%">5th International Conference on Industrial Informatics (INDIN 2007)</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">07/2007</style></date></pub-dates></dates><urls><related-urls><url><style face="normal" font="default" size="100%">http://www.isis.vanderbilt.edu/sites/default/files/Werner.et_.al-INDIN.2007.Paper-PBD4CIS.pdf</style></url></related-urls></urls><pub-location><style face="normal" font="default" size="100%">Vienna, Austria</style></pub-location><abstract><style face="normal" font="default" size="100%">Clinical Information Systems (CIS) have emerged as a new critical infrastructure that influence affordability and security of health care delivery. Complex and conflicting societal requirements, such as providing control for patients over their personal health information and requiring health organizations to assure the security and privacy of patient-specific information, create significant technical challenges for the design of CIS. This paper presents a novel approach that is based on the principles and tools of Model Integrated Computing (MIC), Platform-Based Design (PBD) and Service-Oriented Architectures (SOA). We present a domain-specific, graphical design environment and show how formal system specifications can be mapped to different Service-Oriented Architecture execution platforms through a set of standard languages, such as WSBPEL and XACML. The Model-Integrated Clinical Information Systems (MICIS) design environment includes a suite of domain-specific modeling languages capturing essential aspects of CIS design, model transformation tools that map the domain models onto the standard specification languages of SOA platforms and static model analysis tools checking the consistency and wellformedeness of the multiple-view models. The MICIS design tool is tested in modeling the MyHealth@Vanderbilt patient portal of the Vanderbilt University Medical Center.</style></abstract></record></records></xml>
